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Semen analysis and DNA Fragmentation Index (DFI) are crucial components of male fertility testing. They provide valuable insights into a man’s reproductive health and can help identify potential causes of infertility. Here’s some content explaining these concepts:
Semen analysis is a fundamental test used to evaluate male fertility. It involves examining a semen sample to assess various parameters that can impact a man’s ability to father a child. The key aspects evaluated in a semen analysis include:
An abnormal semen analysis report indicates a poor chance of getting the female partner pregnant. However, it should be noted that a semen analysis is not the only factor in evaluating male factor infertility.
Abnormal semen analysis reports may indicate infertility, infection, hormonal imbalance, underlying diseases (diabetes), and genetic defects.
Semen analysis results also vary on the individual’s age and overall health.
Your fertility doctor will indicate additional testing and screening to confirm or rule out other conditions including:
An abnormal semen analysis report indicates a poor chance of getting the female partner pregnant. However, it should be noted that a semen analysis is not the only factor in evaluating male factor infertility.
Abnormal semen analysis reports may indicate infertility, infection, hormonal imbalance, underlying diseases (diabetes), and genetic defects.
Semen analysis results also vary on the individual’s age and overall health.
If you receive abnormal semen analysis results that indicate low sperm count, you may want to quickly resolve this issue. There are some home remedies and handy tips you can use to boost your sperm count.
Here’s how to increase semen quantity naturally:
Typically, the chance of infertility being attributed to the male partner are between 35% and 40%. The development of a healthy embryo is initiated when the chromosomes in the egg unite with the chromosomes in the sperm. These chromosomes consist of strands of DNA (deoxyribonucleic acid). The function of the sperm is to deliver male DNA to the egg; the quality of DNA delivered can determine the development of the embryo and subsequent milestones during pregnancy.
Presence of fragmented DNA in the sperm has been shown to affect male fertility potential and development of the embryo.It can also be a cause for IVF failure and recurrent miscarriages. High DFI is generally seen in men with advanced age, inflammation of the external genitals and varicocele, unhealthy lifestyle habits such as smoking and alcohol consumption, and environmental radiation and pollution.
Sperm DNA Fragmentation – Around 50% of most conditions of infertility could be connected to a male element.
Benefits
This procedure helps us understand whether the semen sample from the male partner can be used or not. In case the fragmentation is of a higher degree, we suggest employing a sperm donor.
Risks
The risks that stem from sperm DNA fragmentation have no bearing on the health of the male partner. There are, however, some perceived limitations of the procedure.
Causes of Sperm DNA Damage
• Unexplained infertility
• Couples with history of poor or arrested embryonic development
• Multiple failed ART cycles
• Recurrent Miscarriage
• Advanced male age
• Varicocele
• Abnormal semen analysis
• Exposure to harmful substances, tobacco, alcohol, radiation etc.
Since sperm fragmentation deals with the DNA or the genetic material of the sperm, a mere semen analysis is not enough to detect the abnormalities. Specific tests are designed for the same. One of the most commonly used tests is SCSA. SCSA stands Sperm Chromatin Structure Analysis. In this test, the sperm is made to come in contact with a certain chemical dye. If the sperm is broken, its DNA turns red. Similarly, if the sperm is healthy or normal, its DNA turns green. Then, the ratio of the red to green sperm cells is calculated with the help of a specially built software & computer.