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As they travel through the fallopian tubes, sperms gain the ability to fertilize an egg . They undergo two processes: capacitation, where its outer layer is changed, and hyperactivation, which changes the way the spermβs tail moves .To enter the egg, the sperm has to break through a group of cells known as the cumulus oophorus that surround the egg. The sperm dissolves these cells using an enzyme ,acrosin. Once a sperm has penetrated an egg, this membrane changes, and becomes impenetrable to other sperm. It then fuses with the DNA of the egg to form the zygote.
ICSI (IntraCytoplasmic Sperm Injection) β literally translated as βsperm injection into the eggβ. This is the first complementary in vitro fertilization technique that has appeared. Its point is that first the reproductive physician selects a spermatozoon, with the help of an electron microscope, with a magnification of 400-600 times. Thus, he can see all pathologies, mutations, cell activity and chooses the healthiest one. After all, only a full-fledged sperm cell can give a healthy and full-fledged child.
He fixes it and places it in a special, very small needle. Further, with the help of this needle, he pierces the outer shell of the egg and injects the sperm directly into its cytoplasm. Thus, the doctor fertilizes the egg. This happens with all eggs received from a woman.
Then everything happens as in usual IVF: embryo incubation, uterine implantation and a successful pregnancy.
Adding ICSI to IVF significantly increases the chances of successful fertilization and the birth of a healthy child.
Indications:
But the doctors did not stop there, they continued their research and decided that the procedure could be further improved. This was facilitated by technical progress, namely more powerful microscopes. And then a new method appeared β IMSI and PICSI.
PICSI (Physiologic Intra Cytoplasmic Sperm Injection) β if literally, it is translated as βphysiological intracytoplasmic sperm injectionβ. This method is also an addition to the ICSI procedure. But in addition to visual selection, under a magnification of 400 times, the determination of the physiological activity of the sperm cell is also added using special media. They are added to the βtest tubeβ to the sperm, and simulate conditions as close as possible to the penetration of the sperm through all the membranes of the egg.
Thus, the doctor checks the maturity of the sperm, activity, physiological βstrengthβ and the ability to interact with the egg. In his decision, the doctor is guided not only by visual data, but also by the chemical and biological characteristics of the sperm.
Further, the procedure is carried out as in conventional IVF + ICSI. As practice shows, PICSI increases the chances of a successful pregnancy by 25-35%.
IMSI (Intracytoplasmic Morphologically Selected Sperm Injection) β which means βIntracytoplasmic, morphologically selected sperm injectionβ. This technique is an addition to the ICSI procedure. But there is one main difference β this is a microscope. During the IMSI, a magnification of 6000 times is used.
This method became available only when modern, powerful microscopes appeared. This increase allows you to see not only the mobility and vitality of spermatozoa, but also to carry out their morphological selection.
What does it mean? Almost every man has pathologically developed spermatozoa: two heads, bifurcation of the tail, the absence of a nucleus inside the cell, or other mutations, small mutations in the morphological structure of the sperm. Normally, there are only a few such spermatozoa. But, for various reasons, they can become much more and then pregnancy does not occur or does occur, but the child is born with pathologies.
In turn, the IMSI method allows you to select the best sperm and fertilize. Further, the procedure is carried out according to the standard IVF + ICSI protocol.
As practice shows, the additional IMSI procedure raises the success rate of IVF up to 70% even in the most severe cases of male infertility.
The indications for the procedure are the same as for ICSI, but it is additionally recommended to do it if a man or his family has had cases of genetic mutation, pathology and congenital diseases.
Also, the method allows you to almost completely remove the possibility of having a child with pathologies.
So, the IMSI method allows you to select the best sperm and fertilize. Further, the procedure is carried out according to the standard IVF + ICSI protocol.
As practice shows, the additional IMSI procedure raises the success rate of IVF up to 70% even in the most severe cases of male infertility.
The indications for the procedure are the same as for ICSI, but it is additionally recommended to do it if a man or his family has had cases of genetic mutation, pathology and congenital diseases.
Also, the method allows you to almost completely remove the possibility of having a child with pathologies.
1000+ Happy Couples with real stories from IVF patients
My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.
Hello everyone ,Iam very thankful to Indira IVF Noida center for their help.they helped me to achieve pregnancy after 10 years of long wait.it is the Best IVF center in noida.they have the best and supportive staff.most important is Dr Mandavi is very experienced and guides you well.she is the best doctor I will once again thanks the entire Indira IVF Noida team for their immense support π.
Thanks to Dr. Neha and Dr. Mandvi for this immense happiness which is possible just by their guidence and support, I have just started my journey. Special thanks to Ms.Ocean, she is very supportive and ready to answer all the doubts regarding any issue anytime. Thanks to all Indra IVF Noida team, all the members working there are very good and carries a smile on their faces which gives a positive vibes π
Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.
After struggling for last 5 years, We have wonderful experience with the doctor & whole staff of INDIRA IVF NOIDA CENTRE , Doctor Mandavi maβam is very generous & simple . All the staff are very easy going & supportive. I would like to mention the name specially lovely Osheen maβam, Shweta maβam for guiding us in every situation. They are always available on phone call for any guidance & emergencies. They treat like family not like Clint. I would like to thanks Prabhat ji karan ji & all other staff too for their wonderful support . We wish them all the success & best wishes from bottom of our heart. Humble thanks! πππ
Thanks to Indira IVF and all the staff members of Noida centre..I have been trying for 4 years for pregnancy but there were no positive result..Then I heard about Indira IVF and the journey started and now my report is positive in first attempt..I am very greatfull to Dr Mandi Rai and her team...π€©π€©ππ Thanku so much to all of youβ₯οΈ
I am very thankful to all indira ivf noida staff and Dr. Mandavi Rai. Noida centre is one of the best center of indira IVF. Doctor Mandavi Rai is so experienced doctor in her field. All the staff and doctor are very caring and helpful nature.They guide us every time when we need. I conceived my pregnancy in first attempt after 8 years of my marriage. Once again thanks to Dr. Mandavi Rai and her team. Best place for every infertile couple who want to be parents.
We had the best experience with Dr Mandavi Rai and her entire professional Team of Indira IVF Noida. Dr. Mandavi is very professional, caring, knowledgeable and helpful. They all made this journey easy for me. now I am 18 weeks pregnant and baby is on the way!! Thank You. Dr. Mandavi and Team for made our dream come true!!
We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..
Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks
Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks
I would like to thank Dr. Mandavi and the entire Noida team. I conceived in first attempt after 12years of marriage. The whole team is quite humble and helpful and the Dr. Mandavi is very approachable and kindly answers her patientβs questions and concerns. I am glad I chose Indira IVF Noidaπ. I would highly recommend you to consult them if you are struggling with fertility issues. God Bless.
Fortunately we came to Indira Ivf and it is the best place to get it done. My husband and me have been married since last 8 years and got this biggest happy news just because of this centre. Dr Mandavi Rai is extremely efficient in her work and very polite , understanding and positive. Also the complete staff is very helping and supportive. They are there everytime you need them . They follow up with you on time nad take updates. I want to specifically thank Jr Doc, Monica, Osheen, Yamini for thier through out support . You guys rock π. Last but not he least a smiling face Prabhat bhaiya, you are a gem. Priya & Vaibhav Modi
We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..
This Center is a boon to many parents. They are supportive and Caring as well. Doctor and Staff Nurses give great advice and do the follow up on regular basis. Thanks to Noida 18 Indira IVF Team. Receptionist, Medical Store respresentative, Cashier and then the most valuable asset 3 angels π of IVF. junior Doc, Staff Nurse Mam. Thanks Again π
After years trying to conceive, several losses, multiple failed from other fertility clinics with a frustrating diagnosis. I and my wife finally took descision to visit India and decided to choose Indira IVF fertility centre ( Noida , uttar Pradesh). When things aren't working right and you are struggling to get pregnant, this is the doctor you want on your side. Dr. Mandavi Rai is the perfect combination of knowledge and empathy. Each challenge she encounters, she attacks head on, and trust me, my case has a few of them! The phrase " Give up" is not in her vocabulary. She will find a solution. Dr Mandavi Rai's manner is wonderful. Now about staff .... Some of the best people you will ever know. They are all very knowledgeable in their field, treat you with kindness and respect, and makes themselves available for any questions and concerns, oftentimes going above beyond their job description to help you out.πππππ
I had the best time with Dr Mandavi and her team from day one. She is so goood I can't explain in words. Before her I had consulted quite a few others doctors but I couldn't continue with any of them. Dr Mandavi is calm doctor who listens to concerns even if you ask a thousand times and never rushes into conclusions. She will take time to explain and then will help us make our decision. She has became nothing less than my family member and truly cherish my relationship with her. A big portion of her being the way she is goes to the wonderful team she has who are equally responsive, available at midnight, caring and super supportive. I am very thankful to Yamini ji, Monika ji and Prabhat ji and even Wasim ji who always gave a warm smile in my journey. I am very very thankful to everyone and spl Dr Mandavi for just being there for me then and even now and always going forward. Thanks a lot & God bless.
A place where our dream of having a child actually turned to reality is Indira IVF Noida. We would like to thank Doctor Mandavi ma'am and her entire team for this beautiful experience. I conceived my pregnancy in first attempt after 7 years of my marriage. All credit goes to you Mandavi ma'am ππΌβ€οΈ Thank you for your kind and supportive nature throughout our journey. (Whoever is dreaming of becoming a parent, please do get your treatment done at this place.)
I am very grateful to INDIRA IVF NOIDA Teem. They are the best IVF center in Noida. My wife conceived in first attempt. They have the best staff and best services. Dr. Mandavi Rai is the best doctor to consult.They have most affordable treatment plan. Than you soo much INDIRA IVF NOIDA.
I am (Priyanka Rani) sharing my feedback here about Indira IVF Centre. There is no doubt about giving a 5-star rating because Dr. Madam and all the staff are very helpful. They guide us every time, when we needed them (some times on calls or what's up as well). I conceived my pregnancy on my first attempt after six years of marriage. Thanks a lot to Indira IVF (Dr. Mandavi Rai and her staff). It's just advice for Indira IVF call centre that it should be clear on the phone that all the IVF package details are given, and after using medicine, an approximate idea of the amount should be given because some times every person cannot cover medicine and injections after taking the IVF package. Because every person can not do the google for more details and can not contact to their relatives.
I am so thankful to Dr mandavi rai is so experienced in her field. She is the best consultant in noida. My wife conceived after ΰ₯§ΰ₯« years of our marriage. I recommend this indira ivf noida center to all the persons who want to become parents. The staff here is so cooperating and helpful they guide us properly in every time. I am thankful to all staffs here Dr monika, yamini, osheen, prabhat, waseem ππ. # best doctor.
I cannot express how grateful and satisfied I am with my experience at Indira IVF Noida, particularly with Dr. Mandavi Rai's expertise. From the very beginning, she demonstrated a caring and compassionate approach, answering all my questions and concerns with patience and empathy. The entire process was seamless, and I felt well-supported throughout my journey. Dr. Mandavi's knowledge and professionalism instilled confidence in me, and I was thrilled to achieve success in my first attempt at conception. The staff at Indira IVF Noida was also exceptional, providing a warm and welcoming environment that made a significant difference during this emotional and important time. The facilities were modern, clean, and well-maintained. I highly recommend Indira IVF Noida and Dr. Mandavi Rai to anyone seeking fertility treatments. My heartfelt thanks to the entire team for making my dream of becoming a parent a reality.
I am delighted to share my heartfelt appreciation for the outstanding service provided by Indira IVF, Noida , Dr. Mandavi Rai and all the staff there. From the moment we entered the clinic, the warm and friendly atmosphere put us at ease. The professionalism and expertise displayed by the medical team were truly commendable. Their care and compassion throughout our fertility treatment journey were exemplary. Indira IVF's staff went above and beyond, creating an exceptional experience that we would highly recommend to others. Thank you Noida Team .π
We were lost hope to have smile on our face s after diagonized with some critical issue, but Ms Dr. Mandvi Rai Mam and her team put a great effort to bring back smile. Thank you so much Indira IVF noida team. Noida team is very caring. I personally advise to people who are facing such issue please meet with doctors before time is up.
A very big Thanks to Indira IVF . The complete team of Indira IVF is very professional, transparent and responsive. Dr. Mandavi is so calm and her staff is superb.They all were very cooperative. They discussed the thing in detail and suggested all possible options. We were trying for pregnancy for 5 years . And then I got to know about Indira IVF treatment. Here we got success in the first attempt... I am so thankful for the entire team for their support and effort.
Its very good experience at Indra IVF . The success rate is quite high may be above 70%. Dr Mandvi Rai is very good , polite, easily approachable and sincere to her duty. In my opinion Indra IVF is the Best IVF center in Delhi NCR as well as in India. I wish for all Success to Indra IVF and to meet the expectations of the needy couple.
Best IVF center in Noida. I conceived in 1st attempt after 11 years of my marriage. I want to thanks to Dr mandavi rai she is so experienced and expert in her field. Her entire is also so helpful. I also want to thanks to her entire team of indira ivf noida center junior doctor Monika, Yamini, Osheen, Neha, prabhat, Arjun, waseem. Thank you so much for giving us this happiness of parenthood in our live. I highly recommend this center.
I am very grateful to Dr Mandavi Rai for her guidance and support in achieving our pregnancy. it's the best IVF Cneter with est staff and support. All the patients who want to conceive should visit Noida center as they have the best staff and best doctor!!
Amazing experience with the staff and the doctor. Best class support and finally we are in the process of becoming parents. Staff will give personalised support and help throughout the process. Thanks Dr. Mandavi and her team for fulfilling our dream. Kudos and keep up the good work. Highly recommended !!
Dr Mandvi and all her staff from admin, to medical, to reception to assistant everyone is very helpful. They listen to every single problem of yours carefully and will ensure all required support and help is given. We came here after a lot of disappointments. But they ensure the treatment and all alternatives are given in the starting only. Thank you again for the support and understanding
After struggling for last 5 years, We have wonderfulexperience with the doctor & whole staff of INDIRAIVF NOIDA CENTRE , Doctor Mandavi ma'am is verygenerous & simple . All the staff are very easy going& supportive. I would like to mention the namespecially lovely Osheen ma'am, Shweta ma'am forguiding us in every situation. They are alwaysavailable on phone call for any guidance &emergencies. They treat like family not like Clint. Iwould like to thanks Prabhat ji karan ji & all otherstaff too for their wonderful support . We wish themall the success & best wishes from bottom of ourheart. Humble thanks!
Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.
My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.
best staff every one is helping and kind Dr Mandavi mam is so careful and helping and amezing visit for good care
We started visting Indira IVF after a refreaal from Mumbai Indira IVF; Dr.Mandavi and Team are good and have taken good care of the baby during pregnancy; they advised right hospital for delivery and supported us; Thanks to Shevali and Oshi alog with Dr.Mandavi
