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PGT-A/NICS

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PRE-GENETIC TESTING

Infertility affects around 10-15 % of couples and the incidence is much higher in females with advanced age of more than 35 years ( >25%). Also the causes of infertility are different in a couple with advanced age of female partner as compared with a young couple. It is a well known fact that female infertility declines with age and chances of miscarriage are also increased in a women with advanced age. The most important reason for this is the embryonic defects which is mainly due to the defective oocyte quality. So to help these group of patients in achieving a successful pregnancy, we can offer them this newer technology of preimplantation genetic screening. This technique is also a boon for the couples with recurrent IVF failures and recurrent abortions.

Whom to offer – This technique can be offered to patients with following issues

1) Couples with advanced age of female partner (>35 years)

2) Couples with recurrent abortions.

3) Either of the partner is suffering from any single gene disorder or any chromosomal disorder.

4) Patients with recurrent ivf failures.

5) Couples with a previous child affected by any genetic disease.

Procedure Methodology

This procedure needs technical expertise and needs to be done by an embryologist who is skilled enough to carry out the procedure. The couple undergoes an ivf cycle and the resultant embryos are then subjected to biopsy. This can be done on either a day 3 embryo ( 8-cell stage), or a day 5 embryo ( blastocyst stage), however biopsy done at blastocyst stage is preferred. So the technique involves creating a small hole in the outer covering of an embryo ( also known as zona pellucida) with the help of non-contact laser, followed by a biopsy of 1-2 blastomeres from a day 3 embryo or 8 to 10 cells from the trophoectoderm layer of a day 5 embryo.

These cells then undergo genetic analysis either using a FISH technique ( 5 chromosomes including no 13,18,21 X and Y) or CGH array ( entire 23 pair of chromosomes are checked). Since it takes some 10 to 15 days for the results to come, so we need to freeze all embryos followed by the transfer of a genetically normal embryo in the next cycle.

Advantages

This technique is definitely advantageous for those couples with advanced age because it has been observed that as many as 50 percent of grade 1 embryos might not be genetically normal, so when we select them according to their ploidy status, we can improve the ivf outcome and can give them a healthy pregnancy.

Also the patient can go for a single embryo transfer without compromising the success and hence we can reduce the burden of multiple pregnancy and the complications associated with it.

PGT-A, PGT-M and PGT-SR.

PGT-A

This type of PGT identifies chromosomal abnormalities. Each parent contributes their biological material resulting in 23 chromosomes from each (46 chromosomes or 23 pairs). If the embryo cell is missing a chromosome or there is an extra chromosome it’s called aneuploidy, the “A” in “PGT-A”. A missing chromosome is monosomy, and an additional chromosome is trisomy.

Aneuploidy is one of the leading causes of miscarriage and failed IVF. An embryo can only survive one type of monosomy. Turner’s syndrome which is the absence of one of the X chromosomes. Trisomy may result in a live birth however the baby may have Down syndrome or the more devastating pate syndrome or Edward syndrome in which the baby only survives a short time.

PGT-M

This test looks for a known gene mutation which the biological parent carries. A family history of a genetic condition provides the cause for PGT-M. When a genetic disorder involves a single specific gene it’s due to a mutation in the DNA sequence. Some of these gene mutations cause cystic fibrosis or sickle cell disorder. Some genes identify a high risk for developing certain cancers such as breast or ovarian cancers (BRCA-1 or BRCA-2). Other common gene mutations discovered via PGT-M:

 

  • Huntington’s Disease
  • Tay-Sachs Disease
  • Muscular Dystrophy
  • Fragile-X Syndrome

PGT-SR

Doctors refer to this testing as PGT-SR because the SR stands for structural rearrangements. Biological parents with a known structural rearrangement have inverted or translocated chromosomes. These individuals produce embryos without the correct amount of chromosomal material. That results in loss of the pregnancy. Your doctor recommends PGT-SR if you’ve experienced multiple miscarriages.

If your test reveals a structural rearrangement, you may benefit from donor eggs or sperm.

 

What is Non-Invasive Chromosomal Screening NICS?

Non-invasive chromosomal screening (NICS) is a breakthrough emerging technology in fertility industry. NICS enables us to identify genetically normal embryos to be transferred into the mother’s uterus (womb) and most importantly – without needing an embryo biopsy. By doing so, we avoid unnecessary embryo transfers with genetically abnormal embryos. This indirectly increases success rate of the IVF cycle. In summary – it reduces the time to pregnancy.

Which couples get benefitted with NICS?

  • Couples with mother over the age of 35
  • Women who had recurrent pregnancy loss
  • Women who had multiple (>2) failed IVF cycles
  • Couples with family history of genetic issues
  • Couples with previous genetically affected baby

What happened during NICS procedure?

  • Initial 3 days is same as any Intracytoplasmic Sperm Injection (ICSI)
  • Well progressed embryos are cultured individually until 5 days.
  • As the embryo evolves, the cell free DNA from the blastocytes cells spread into the culture media.
  • A very tiny amount (20 microliters) of this culture medium is sent to the genetic lab for testing chromosomal makeup.
  • The embryo is left undistributed and is frozen in liquid nitrogen at -1970
  • No biopsy done.

How long does the report take?

Report can take up to 3-4 weeks.


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What does the report say?

Report may say

  • Embryo is normal and suitable/recommended for embryo transfer
  • Embryo is abnormal and not suitable/not recommended for embryo transfer
  • Embryo is mosaic (slightly abnormal) and is recommended for embryo transfer with caution. In such cases, once the woman is pregnant up to 4 months, fluid around the baby is sent for chromosomal screening (amniocentesis and karyotyping)

What are the benefits of NICS Procedure

  • Non-traumatic and effective method for screening the embryos
  • Does not affect the embryo (Non-Invasive)
  • Increases chances of successful implantation of embryo
  • Saves time of unsuccessful pregnancies and avoidable visits
  • Alternative to invasive embryo biopsy (PGT-A)

Difference between PGT-A and NICS

Preimplantation genetic testing for anomalies (PGT-A) is an invasive embryo biopsy procedure which involves taking a biopsy of few cells from Day 5 embryo i.e., the blastocytes.

  • PGT is an invasive procedure and the NICS is Noninvasive.
  • PGT requires embryo biopsy, NICS does not involve embryo biopsy.
  • In PGT-A few cells from outer layer of the blastocyst stage embryo are sent for genetic testing, where as in NICS embryo is untouched and the culture medium is sent for genetic screening.
  • NICS is a safer procedure and gives equal success rates and long-term outcomes and safety of the offspring as in comparison with PGT-A, with no biopsy.

Testimonial

1000+ Happy Couples with real stories from IVF patients

My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.

Surendra Pal

Hello everyone ,Iam very thankful to Indira IVF Noida center for their help.they helped me to achieve pregnancy after 10 years of long wait.it is the Best IVF center in noida.they have the best and supportive staff.most important is Dr Mandavi is very experienced and guides you well.she is the best doctor I will once again thanks the entire Indira IVF Noida team for their immense support 😘.

Ayush Gujjar

Thanks to Dr. Neha and Dr. Mandvi for this immense happiness which is possible just by their guidence and support, I have just started my journey. Special thanks to Ms.Ocean, she is very supportive and ready to answer all the doubts regarding any issue anytime. Thanks to all Indra IVF Noida team, all the members working there are very good and carries a smile on their faces which gives a positive vibes 🙏

neha chaudhary

Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.

mitul makwana

After struggling for last 5 years, We have wonderful experience with the doctor & whole staff of INDIRA IVF NOIDA CENTRE , Doctor Mandavi ma’am is very generous & simple . All the staff are very easy going & supportive. I would like to mention the name specially lovely Osheen ma’am, Shweta ma’am for guiding us in every situation. They are always available on phone call for any guidance & emergencies. They treat like family not like Clint. I would like to thanks Prabhat ji karan ji & all other staff too for their wonderful support . We wish them all the success & best wishes from bottom of our heart. Humble thanks! 🙏🙏🙏

PRIYA TIWARI

Thanks to Indira IVF and all the staff members of Noida centre..I have been trying for 4 years for pregnancy but there were no positive result..Then I heard about Indira IVF and the journey started and now my report is positive in first attempt..I am very greatfull to Dr Mandi Rai and her team...🤩🤩😊😊 Thanku so much to all of you♥️

jayant Kumar

I am very thankful to all indira ivf noida staff and Dr. Mandavi Rai. Noida centre is one of the best center of indira IVF. Doctor Mandavi Rai is so experienced doctor in her field. All the staff and doctor are very caring and helpful nature.They guide us every time when we need. I conceived my pregnancy in first attempt after 8 years of my marriage. Once again thanks to Dr. Mandavi Rai and her team. Best place for every infertile couple who want to be parents.

Radha thakuri

We had the best experience with Dr Mandavi Rai and her entire professional Team of Indira IVF Noida. Dr. Mandavi is very professional, caring, knowledgeable and helpful. They all made this journey easy for me. now I am 18 weeks pregnant and baby is on the way!! Thank You. Dr. Mandavi and Team for made our dream come true!!

Madhuri Mishra

We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..

Richa Sharma

Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks

Amit Sinha

Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks

Amit Sinha

I would like to thank Dr. Mandavi and the entire Noida team. I conceived in first attempt after 12years of marriage. The whole team is quite humble and helpful and the Dr. Mandavi is very approachable and kindly answers her patient’s questions and concerns. I am glad I chose Indira IVF Noida😊. I would highly recommend you to consult them if you are struggling with fertility issues. God Bless.

Ritu Singh

Fortunately we came to Indira Ivf and it is the best place to get it done. My husband and me have been married since last 8 years and got this biggest happy news just because of this centre. Dr Mandavi Rai is extremely efficient in her work and very polite , understanding and positive. Also the complete staff is very helping and supportive. They are there everytime you need them . They follow up with you on time nad take updates. I want to specifically thank Jr Doc, Monica, Osheen, Yamini for thier through out support . You guys rock 😃. Last but not he least a smiling face Prabhat bhaiya, you are a gem. Priya & Vaibhav Modi

Priya Gupta

We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..

Richa Sharma

This Center is a boon to many parents. They are supportive and Caring as well. Doctor and Staff Nurses give great advice and do the follow up on regular basis. Thanks to Noida 18 Indira IVF Team. Receptionist, Medical Store respresentative, Cashier and then the most valuable asset 3 angels 😇 of IVF. junior Doc, Staff Nurse Mam. Thanks Again 👍

Divakar nigam

After years trying to conceive, several losses, multiple failed from other fertility clinics with a frustrating diagnosis. I and my wife finally took descision to visit India and decided to choose Indira IVF fertility centre ( Noida , uttar Pradesh). When things aren't working right and you are struggling to get pregnant, this is the doctor you want on your side. Dr. Mandavi Rai is the perfect combination of knowledge and empathy. Each challenge she encounters, she attacks head on, and trust me, my case has a few of them! The phrase " Give up" is not in her vocabulary. She will find a solution. Dr Mandavi Rai's manner is wonderful. Now about staff .... Some of the best people you will ever know. They are all very knowledgeable in their field, treat you with kindness and respect, and makes themselves available for any questions and concerns, oftentimes going above beyond their job description to help you out.👍👍👍👍👍

Manjil Mandal

I had the best time with Dr Mandavi and her team from day one. She is so goood I can't explain in words. Before her I had consulted quite a few others doctors but I couldn't continue with any of them. Dr Mandavi is calm doctor who listens to concerns even if you ask a thousand times and never rushes into conclusions. She will take time to explain and then will help us make our decision. She has became nothing less than my family member and truly cherish my relationship with her. A big portion of her being the way she is goes to the wonderful team she has who are equally responsive, available at midnight, caring and super supportive. I am very thankful to Yamini ji, Monika ji and Prabhat ji and even Wasim ji who always gave a warm smile in my journey. I am very very thankful to everyone and spl Dr Mandavi for just being there for me then and even now and always going forward. Thanks a lot & God bless.

Urvashi Dube

A place where our dream of having a child actually turned to reality is Indira IVF Noida. We would like to thank Doctor Mandavi ma'am and her entire team for this beautiful experience. I conceived my pregnancy in first attempt after 7 years of my marriage. All credit goes to you Mandavi ma'am 🙏🏼❤️ Thank you for your kind and supportive nature throughout our journey. (Whoever is dreaming of becoming a parent, please do get your treatment done at this place.)

Saroj

I am very grateful to INDIRA IVF NOIDA Teem. They are the best IVF center in Noida. My wife conceived in first attempt. They have the best staff and best services. Dr. Mandavi Rai is the best doctor to consult.They have most affordable treatment plan. Than you soo much INDIRA IVF NOIDA.

Vedprakash Sharma

I am (Priyanka Rani) sharing my feedback here about Indira IVF Centre. There is no doubt about giving a 5-star rating because Dr. Madam and all the staff are very helpful. They guide us every time, when we needed them (some times on calls or what's up as well). I conceived my pregnancy on my first attempt after six years of marriage. Thanks a lot to Indira IVF (Dr. Mandavi Rai and her staff). It's just advice for Indira IVF call centre that it should be clear on the phone that all the IVF package details are given, and after using medicine, an approximate idea of the amount should be given because some times every person cannot cover medicine and injections after taking the IVF package. Because every person can not do the google for more details and can not contact to their relatives.

Piku Rani

I am so thankful to Dr mandavi rai is so experienced in her field. She is the best consultant in noida. My wife conceived after १५ years of our marriage. I recommend this indira ivf noida center to all the persons who want to become parents. The staff here is so cooperating and helpful they guide us properly in every time. I am thankful to all staffs here Dr monika, yamini, osheen, prabhat, waseem 😊😊. # best doctor.

Jagdish Chhimwal

I cannot express how grateful and satisfied I am with my experience at Indira IVF Noida, particularly with Dr. Mandavi Rai's expertise. From the very beginning, she demonstrated a caring and compassionate approach, answering all my questions and concerns with patience and empathy. The entire process was seamless, and I felt well-supported throughout my journey. Dr. Mandavi's knowledge and professionalism instilled confidence in me, and I was thrilled to achieve success in my first attempt at conception. The staff at Indira IVF Noida was also exceptional, providing a warm and welcoming environment that made a significant difference during this emotional and important time. The facilities were modern, clean, and well-maintained. I highly recommend Indira IVF Noida and Dr. Mandavi Rai to anyone seeking fertility treatments. My heartfelt thanks to the entire team for making my dream of becoming a parent a reality.

Abhi Gupta

I am delighted to share my heartfelt appreciation for the outstanding service provided by Indira IVF, Noida , Dr. Mandavi Rai and all the staff there. From the moment we entered the clinic, the warm and friendly atmosphere put us at ease. The professionalism and expertise displayed by the medical team were truly commendable. Their care and compassion throughout our fertility treatment journey were exemplary. Indira IVF's staff went above and beyond, creating an exceptional experience that we would highly recommend to others. Thank you Noida Team .😊

Sachin Tripathi

We were lost hope to have smile on our face s after diagonized with some critical issue, but Ms Dr. Mandvi Rai Mam and her team put a great effort to bring back smile. Thank you so much Indira IVF noida team. Noida team is very caring. I personally advise to people who are facing such issue please meet with doctors before time is up.

BRIJBHAN CHAUHAN

A very big Thanks to Indira IVF . The complete team of Indira IVF is very professional, transparent and responsive. Dr. Mandavi is so calm and her staff is superb.They all were very cooperative. They discussed the thing in detail and suggested all possible options. We were trying for pregnancy for 5 years . And then I got to know about Indira IVF treatment. Here we got success in the first attempt... I am so thankful for the entire team for their support and effort.

Neelam Pankaj

Its very good experience at Indra IVF . The success rate is quite high may be above 70%. Dr Mandvi Rai is very good , polite, easily approachable and sincere to her duty. In my opinion Indra IVF is the Best IVF center in Delhi NCR as well as in India. I wish for all Success to Indra IVF and to meet the expectations of the needy couple.

Raj Pratap Verma

Best IVF center in Noida. I conceived in 1st attempt after 11 years of my marriage. I want to thanks to Dr mandavi rai she is so experienced and expert in her field. Her entire is also so helpful. I also want to thanks to her entire team of indira ivf noida center junior doctor Monika, Yamini, Osheen, Neha, prabhat, Arjun, waseem. Thank you so much for giving us this happiness of parenthood in our live. I highly recommend this center.

Chanchala Chaudhary

I am very grateful to Dr Mandavi Rai for her guidance and support in achieving our pregnancy. it's the best IVF Cneter with est staff and support. All the patients who want to conceive should visit Noida center as they have the best staff and best doctor!!

Ram Vilash

Amazing experience with the staff and the doctor. Best class support and finally we are in the process of becoming parents. Staff will give personalised support and help throughout the process. Thanks Dr. Mandavi and her team for fulfilling our dream. Kudos and keep up the good work. Highly recommended !!

Sarvesh Pandey

Dr Mandvi and all her staff from admin, to medical, to reception to assistant everyone is very helpful. They listen to every single problem of yours carefully and will ensure all required support and help is given. We came here after a lot of disappointments. But they ensure the treatment and all alternatives are given in the starting only. Thank you again for the support and understanding

The Makeup Diaries!!

After struggling for last 5 years, We have wonderfulexperience with the doctor & whole staff of INDIRAIVF NOIDA CENTRE , Doctor Mandavi ma'am is verygenerous & simple . All the staff are very easy going& supportive. I would like to mention the namespecially lovely Osheen ma'am, Shweta ma'am forguiding us in every situation. They are alwaysavailable on phone call for any guidance &emergencies. They treat like family not like Clint. Iwould like to thanks Prabhat ji karan ji & all otherstaff too for their wonderful support . We wish themall the success & best wishes from bottom of ourheart. Humble thanks!

PRIYA TIWARI

Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.

Mitul Makwana

My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.

Surendra Pal

best staff every one is helping and kind Dr Mandavi mam is so careful and helping and amezing visit for good care

Geetika Agarwal

We started visting Indira IVF after a refreaal from Mumbai Indira IVF; Dr.Mandavi and Team are good and have taken good care of the baby during pregnancy; they advised right hospital for delivery and supported us; Thanks to Shevali and Oshi alog with Dr.Mandavi

Parkash Gurazada
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