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IVF

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How does IVF work?

IVF stands for in vitro fertilization. It’s one of the more widely known types of assisted reproductive technology (ART).  IVF works by using a combination of medicines and surgical procedures to help sperm fertilize an egg, and help the fertilized egg implant in your uterus.

IVF has many steps, and it takes several months to complete the whole process. It sometimes works on the first try, but many people need more than 1 round of IVF to get pregnant. IVF definitely increases your chances of pregnancy if you’re having fertility problems, but there’s no guarantee — everyone’s body is different and IVF won’t work for everyone.

 

Why is IVF performed?

People choose IVF for many reasons, including  infertility issues or when one partner has an existing health condition. Some people will try IVF after other fertility methods have failed or if they’re at an advanced maternal age. IVF is also a reproductive option for same-sex couples or people who wish to have a baby without a partner.

IVF is an option if you or your partner has:

  • Blocked or damaged fallopian tubes.
  • Endometriosis
  • Low sperm count or other sperm impairments.
  • PCOS or POF
  • Fibroids
  • Problems with your uterus.
  • Risk of passing on a genetic disease or disorder.
  • Unexplained Infertility
  • Are using an egg donor or a gestational surrogate

What are the steps of IVF treatment?

IVF can be broken down into the following steps:

Ovarian stimulation

During each natural cycle in a healthy person of reproductive age, a group of eggs begins to mature each month. Typically, only one egg becomes mature enough to ovulate. The remaining immature eggs in that group disintegrate.

During your IVF cycle, you’ll take injectable hormone medications to encourage the entire group of that cycle’s eggs to mature simultaneously and fully. This means, instead of having just one egg (like in a natural cycle), you may have many eggs. The type, dosage and frequency of medications prescribed will be tailored to you as an individual based on your medical history, age, AMH (anti-mullerian hormone) level and your response to ovarian stimulation during previous IVF cycles.

The other steps in the ovarian stimulation process include:

  • Monitoring: Your ovaries’ response to the medications is monitored by ultrasound and blood hormone levels. Monitoring can occur daily or every few days over two weeks. Most stimulations last between eight and 14 days. At monitoring appointments, healthcare providers use ultrasound to look at your uterus and ovaries. The eggs themselves are too small to be visible with ultrasound. But, your healthcare providers will measure the size and number of growing ovarian follicles. Follicles are little sacks within your ovaries that should each contain a single egg. The size of each follicle indicates the maturity of the egg it contains. Most follicles greater than 14 millimeters (mm) contain a mature egg. The eggs contained within follicles less than 14 mm are more likely be immature and won’t fertilize.
  • Trigger shot: When your eggs are ready for final maturation (determined by your ultrasound and hormone levels), a “trigger shot” is given to finalize the maturation of your eggs in preparation for egg retrieval. You’ll be instructed to administer the trigger shot exactly 36 hours before your scheduled egg retrieval time.

Egg retrieval

  • Your healthcare provider uses an ultrasound to guide a thin needle into each of your ovaries through your vagina. The needle is connected to a suction device used to pull your eggs out of each follicle.
  • Your eggs are placed in a dish containing a special solution. The dish is then put in an incubator (controlled environment).
  • Medication and mild sedation are used to reduce discomfort during this procedure.
  • Egg retrieval is done 36 hours after your last hormone injection, the “trigger shot.”

Fertilization

The afternoon after your egg retrieval procedure, the embryologist will try to fertilize all mature eggs using intracytoplasmic sperm injection, or ICSI. This means that sperm will be injected into each mature egg. Immature eggs cannot have ICSI performed on them. The immature eggs will be placed in a dish with sperm and nutrients. Immature eggs rarely finish their maturation process in the dish. If an immature egg does mature, the sperm in the dish can then attempt to fertilize the egg.

On average, 70% of mature eggs will fertilize. For example, if 10 mature eggs are retrieved, about seven will fertilize. If successful, the fertilized egg will become an embryo.

If there are an exceedingly large number of eggs or you don’t want all eggs fertilized, some eggs may be frozen before fertilization for future use.

Embryo development

Over the next five to six days, the development of your embryos will be carefully monitored.

Your embryo must overcome significant hurdles to become an embryo suitable for transfer to your uterus. On average, 50% of fertilized embryos progress to the blastocyst stage. This is the stage most suitable for transfer to your uterus. For example, if seven eggs were fertilized, three or four of them might develop to the blastocyst stage. The remaining 50% typically fail to progress and are discarded.

All embryos suitable for transfer will be frozen on day five or six of fertilization to be used for future embryo transfers.

Embryo transfer

There are two kinds of embryo transfers: fresh embryo transfer and frozen embryo transfer. Your healthcare provider can discuss using fresh or frozen embryos with you and decide what’s best based on your unique situation. Both frozen and fresh embryo transfers follow the same transfer process. The main difference is implied by the name.

A fresh embryo transfer means your embryo is inserted into your uterus between three and seven days after the egg retrieval procedure. This embryo hasn’t been frozen and is “fresh.”

A frozen embryo transfer means that frozen embryos (from a previous IVF cycle or donor eggs) are thawed and inserted into your uterus. This is a more common practice for logistical reasons and because this method is more likely to result in a live birth. Frozen embryo transfers can occur years after egg retrieval and fertilization.

As part of the first step in a frozen embryo transfer, you’ll take oral, injectable, vaginal or transdermal hormones to prepare your uterus for accepting an embryo. Usually, this is 14 to 21 days of oral medication followed by six days of injections. Typically, you’ll have two or three appointments during this time to monitor the readiness of your uterus with ultrasound and to measure your hormone levels with a blood test. When your uterus is ready, you’ll be scheduled for the embryo transfer procedure.

The process is similar if you’re using fresh embryos, except embryo transfer happens within three to five days of being retrieved.

The embryo transfer is a simple procedure that doesn’t require anesthesia. It feels similar to a pelvic exam or Pap smear. A speculum is placed within the vagina, and a thin catheter is inserted through the cervix into the uterus. A syringe attached to the other end of the catheter contains one or more embryos. The embryos are injected it the uterus through the catheter. The procedure typically takes less than 10 minutes.

Pregnancy

Pregnancy occurs when the embryo implants itself into the lining of your uterus. Your healthcare provider will use a blood test to determine if you’re pregnant approximately nine to 14 days after embryo transfer.

 

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What are the risks of IVF?

There are several risks associated with IVF treatment:

  • Multiple births: A pregnancy with multiple babies carries a higher risk of premature labor.
  • Premature Delivery: You may have a slightly higher risk of your baby being born early or at a lower birth weight.
  • Miscarriage: The rate of miscarriage is about the same as pregnancies from natural conception.
  • Ectopic pregnancy: This is a condition where your fertilized egg implants outside of your uterus.
  • Complications during egg retrieval: Bleeding, infection and damage to your bladder, bowel or reproductive organs during the egg retrieval process.
  • Ovarian hyperstimulation syndrome (OHSS): A rare condition that causes abdominal pain, nausea, vomiting, diarrhea, rapid weight gain, bloating, shortness of breath and inability to urinate.

What are the most common side effects of IVF?

Some experience side effects from the fertility medications used during the ovulation stimulation phase of IVF. These include:

  • Nausea and vomiting.
  • Hot flashes.
  • Headaches.
  • Enlargement of their ovaries.
  • Abdominal Pain
  • Bruising from IVF injections.

After the transfer of your embryo, you should be able to resume normal activities. Your ovaries will be enlarged, and some discomfort may occur. Common side effects after embryo transfer are:

  • Constipation
  • Bloating.
  • Cramping.
  • Breast tenderness (from high estrogen).
  • Spotting.

IVF can be difficult — both physically and emotionally. Many people doing IVF treatment struggle with depression and anxiety. Infertility struggles and IVF can leave people feeling disappointed or overwhelmed. Talk with your healthcare provider about how you’re feeling so they can offer support through the process.

 

What is the success rate of IVF by age?

Data collected in the U.S .is measured per egg retrieval, not per cycle. The average percentage of live births per egg retrieval in 2019 was:

  • Younger than 35: 46.7%
  • Ages 35 to 37: 34.2%
  • Ages 38 to 40: 21.6%
  • Ages 41 to 42: 10.6%
  • Ages 43 and up: 3.2%

Why do IVF treatments fail?

IVF treatments can fail for many reasons and at any step in the IVF process. Some reasons an IVF cycle fails are:

  • Premature ovulation.
  • No eggs are developing.
  • Too many eggs are developing.
  • Egg isn’t fertilized by sperm.
  • Sperm quality.
  • Embryo stops growing or will not implant.
  • Problems with egg retrieval or embryo transfer.

Your healthcare provider will be able to examine each step of the process with you and determine how to best move forward with future treatments.

Can IVF cause birth defects?

It’s not entirely known if IVF alone is responsible for birth defects. For non-IVF pregnancies, around 2% of all children will be born with a birth defect. Some studies show a slightly higher risk for babies born through IVF. This could be due to delayed conception or related to the underlying cause of infertility.

Embark on Your IVF Journey in Noida:

We invite you to take the first step toward fulfilling your dreams of parenthood by partnering with our renowned IVF center in Noida at INDIRA IVF NOIDA with Dr Mandavi Rai. Our compassionate team is here to provide unwavering support, innovative solutions, and expert care throughout your fertility journey. Contact us today to schedule a consultation and embark on a pathway to parenthood that is backed by excellence, compassion, and success. Your future family is waiting, and we’re here to help you make it a reality.

Testimonial

1000+ Happy Couples with real stories from IVF patients

My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.

Surendra Pal

Hello everyone ,Iam very thankful to Indira IVF Noida center for their help.they helped me to achieve pregnancy after 10 years of long wait.it is the Best IVF center in noida.they have the best and supportive staff.most important is Dr Mandavi is very experienced and guides you well.she is the best doctor I will once again thanks the entire Indira IVF Noida team for their immense support 😘.

Ayush Gujjar

Thanks to Dr. Neha and Dr. Mandvi for this immense happiness which is possible just by their guidence and support, I have just started my journey. Special thanks to Ms.Ocean, she is very supportive and ready to answer all the doubts regarding any issue anytime. Thanks to all Indra IVF Noida team, all the members working there are very good and carries a smile on their faces which gives a positive vibes 🙏

neha chaudhary

Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.

mitul makwana

After struggling for last 5 years, We have wonderful experience with the doctor & whole staff of INDIRA IVF NOIDA CENTRE , Doctor Mandavi ma’am is very generous & simple . All the staff are very easy going & supportive. I would like to mention the name specially lovely Osheen ma’am, Shweta ma’am for guiding us in every situation. They are always available on phone call for any guidance & emergencies. They treat like family not like Clint. I would like to thanks Prabhat ji karan ji & all other staff too for their wonderful support . We wish them all the success & best wishes from bottom of our heart. Humble thanks! 🙏🙏🙏

PRIYA TIWARI

Thanks to Indira IVF and all the staff members of Noida centre..I have been trying for 4 years for pregnancy but there were no positive result..Then I heard about Indira IVF and the journey started and now my report is positive in first attempt..I am very greatfull to Dr Mandi Rai and her team...🤩🤩😊😊 Thanku so much to all of you♥️

jayant Kumar

I am very thankful to all indira ivf noida staff and Dr. Mandavi Rai. Noida centre is one of the best center of indira IVF. Doctor Mandavi Rai is so experienced doctor in her field. All the staff and doctor are very caring and helpful nature.They guide us every time when we need. I conceived my pregnancy in first attempt after 8 years of my marriage. Once again thanks to Dr. Mandavi Rai and her team. Best place for every infertile couple who want to be parents.

Radha thakuri

We had the best experience with Dr Mandavi Rai and her entire professional Team of Indira IVF Noida. Dr. Mandavi is very professional, caring, knowledgeable and helpful. They all made this journey easy for me. now I am 18 weeks pregnant and baby is on the way!! Thank You. Dr. Mandavi and Team for made our dream come true!!

Madhuri Mishra

We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..

Richa Sharma

Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks

Amit Sinha

Indira IVF Noida Sec 18: A team of very supportive staff and well experienced Dr. Mandavi Rai. After 7 years of marriage, we lost hope of having kids.Then we visited Indira IVF Sec 18 Noida and we got positive result under the expertise and professional team. Thanks to entire team and especially Dr. Mandavi Rai for make our dream comes true. If some1 have lost hope of having kids than must visit and consult Dr. Mandavi Rai and team. Thanks

Amit Sinha

I would like to thank Dr. Mandavi and the entire Noida team. I conceived in first attempt after 12years of marriage. The whole team is quite humble and helpful and the Dr. Mandavi is very approachable and kindly answers her patient’s questions and concerns. I am glad I chose Indira IVF Noida😊. I would highly recommend you to consult them if you are struggling with fertility issues. God Bless.

Ritu Singh

Fortunately we came to Indira Ivf and it is the best place to get it done. My husband and me have been married since last 8 years and got this biggest happy news just because of this centre. Dr Mandavi Rai is extremely efficient in her work and very polite , understanding and positive. Also the complete staff is very helping and supportive. They are there everytime you need them . They follow up with you on time nad take updates. I want to specifically thank Jr Doc, Monica, Osheen, Yamini for thier through out support . You guys rock 😃. Last but not he least a smiling face Prabhat bhaiya, you are a gem. Priya & Vaibhav Modi

Priya Gupta

We were trying for a long time for a baby but we failed everytime... When we came to Indira ivf centre , they helped us in every stage of our treatment and finally I got positive result ..... My whole journey during IVF dr. Mandavi mam guided us so well . Thank you so much for bringing happiness in our life..

Richa Sharma

This Center is a boon to many parents. They are supportive and Caring as well. Doctor and Staff Nurses give great advice and do the follow up on regular basis. Thanks to Noida 18 Indira IVF Team. Receptionist, Medical Store respresentative, Cashier and then the most valuable asset 3 angels 😇 of IVF. junior Doc, Staff Nurse Mam. Thanks Again 👍

Divakar nigam

After years trying to conceive, several losses, multiple failed from other fertility clinics with a frustrating diagnosis. I and my wife finally took descision to visit India and decided to choose Indira IVF fertility centre ( Noida , uttar Pradesh). When things aren't working right and you are struggling to get pregnant, this is the doctor you want on your side. Dr. Mandavi Rai is the perfect combination of knowledge and empathy. Each challenge she encounters, she attacks head on, and trust me, my case has a few of them! The phrase " Give up" is not in her vocabulary. She will find a solution. Dr Mandavi Rai's manner is wonderful. Now about staff .... Some of the best people you will ever know. They are all very knowledgeable in their field, treat you with kindness and respect, and makes themselves available for any questions and concerns, oftentimes going above beyond their job description to help you out.👍👍👍👍👍

Manjil Mandal

I had the best time with Dr Mandavi and her team from day one. She is so goood I can't explain in words. Before her I had consulted quite a few others doctors but I couldn't continue with any of them. Dr Mandavi is calm doctor who listens to concerns even if you ask a thousand times and never rushes into conclusions. She will take time to explain and then will help us make our decision. She has became nothing less than my family member and truly cherish my relationship with her. A big portion of her being the way she is goes to the wonderful team she has who are equally responsive, available at midnight, caring and super supportive. I am very thankful to Yamini ji, Monika ji and Prabhat ji and even Wasim ji who always gave a warm smile in my journey. I am very very thankful to everyone and spl Dr Mandavi for just being there for me then and even now and always going forward. Thanks a lot & God bless.

Urvashi Dube

A place where our dream of having a child actually turned to reality is Indira IVF Noida. We would like to thank Doctor Mandavi ma'am and her entire team for this beautiful experience. I conceived my pregnancy in first attempt after 7 years of my marriage. All credit goes to you Mandavi ma'am 🙏🏼❤️ Thank you for your kind and supportive nature throughout our journey. (Whoever is dreaming of becoming a parent, please do get your treatment done at this place.)

Saroj

I am very grateful to INDIRA IVF NOIDA Teem. They are the best IVF center in Noida. My wife conceived in first attempt. They have the best staff and best services. Dr. Mandavi Rai is the best doctor to consult.They have most affordable treatment plan. Than you soo much INDIRA IVF NOIDA.

Vedprakash Sharma

I am (Priyanka Rani) sharing my feedback here about Indira IVF Centre. There is no doubt about giving a 5-star rating because Dr. Madam and all the staff are very helpful. They guide us every time, when we needed them (some times on calls or what's up as well). I conceived my pregnancy on my first attempt after six years of marriage. Thanks a lot to Indira IVF (Dr. Mandavi Rai and her staff). It's just advice for Indira IVF call centre that it should be clear on the phone that all the IVF package details are given, and after using medicine, an approximate idea of the amount should be given because some times every person cannot cover medicine and injections after taking the IVF package. Because every person can not do the google for more details and can not contact to their relatives.

Piku Rani

I am so thankful to Dr mandavi rai is so experienced in her field. She is the best consultant in noida. My wife conceived after १५ years of our marriage. I recommend this indira ivf noida center to all the persons who want to become parents. The staff here is so cooperating and helpful they guide us properly in every time. I am thankful to all staffs here Dr monika, yamini, osheen, prabhat, waseem 😊😊. # best doctor.

Jagdish Chhimwal

I cannot express how grateful and satisfied I am with my experience at Indira IVF Noida, particularly with Dr. Mandavi Rai's expertise. From the very beginning, she demonstrated a caring and compassionate approach, answering all my questions and concerns with patience and empathy. The entire process was seamless, and I felt well-supported throughout my journey. Dr. Mandavi's knowledge and professionalism instilled confidence in me, and I was thrilled to achieve success in my first attempt at conception. The staff at Indira IVF Noida was also exceptional, providing a warm and welcoming environment that made a significant difference during this emotional and important time. The facilities were modern, clean, and well-maintained. I highly recommend Indira IVF Noida and Dr. Mandavi Rai to anyone seeking fertility treatments. My heartfelt thanks to the entire team for making my dream of becoming a parent a reality.

Abhi Gupta

I am delighted to share my heartfelt appreciation for the outstanding service provided by Indira IVF, Noida , Dr. Mandavi Rai and all the staff there. From the moment we entered the clinic, the warm and friendly atmosphere put us at ease. The professionalism and expertise displayed by the medical team were truly commendable. Their care and compassion throughout our fertility treatment journey were exemplary. Indira IVF's staff went above and beyond, creating an exceptional experience that we would highly recommend to others. Thank you Noida Team .😊

Sachin Tripathi

We were lost hope to have smile on our face s after diagonized with some critical issue, but Ms Dr. Mandvi Rai Mam and her team put a great effort to bring back smile. Thank you so much Indira IVF noida team. Noida team is very caring. I personally advise to people who are facing such issue please meet with doctors before time is up.

BRIJBHAN CHAUHAN

A very big Thanks to Indira IVF . The complete team of Indira IVF is very professional, transparent and responsive. Dr. Mandavi is so calm and her staff is superb.They all were very cooperative. They discussed the thing in detail and suggested all possible options. We were trying for pregnancy for 5 years . And then I got to know about Indira IVF treatment. Here we got success in the first attempt... I am so thankful for the entire team for their support and effort.

Neelam Pankaj

Its very good experience at Indra IVF . The success rate is quite high may be above 70%. Dr Mandvi Rai is very good , polite, easily approachable and sincere to her duty. In my opinion Indra IVF is the Best IVF center in Delhi NCR as well as in India. I wish for all Success to Indra IVF and to meet the expectations of the needy couple.

Raj Pratap Verma

Best IVF center in Noida. I conceived in 1st attempt after 11 years of my marriage. I want to thanks to Dr mandavi rai she is so experienced and expert in her field. Her entire is also so helpful. I also want to thanks to her entire team of indira ivf noida center junior doctor Monika, Yamini, Osheen, Neha, prabhat, Arjun, waseem. Thank you so much for giving us this happiness of parenthood in our live. I highly recommend this center.

Chanchala Chaudhary

I am very grateful to Dr Mandavi Rai for her guidance and support in achieving our pregnancy. it's the best IVF Cneter with est staff and support. All the patients who want to conceive should visit Noida center as they have the best staff and best doctor!!

Ram Vilash

Amazing experience with the staff and the doctor. Best class support and finally we are in the process of becoming parents. Staff will give personalised support and help throughout the process. Thanks Dr. Mandavi and her team for fulfilling our dream. Kudos and keep up the good work. Highly recommended !!

Sarvesh Pandey

Dr Mandvi and all her staff from admin, to medical, to reception to assistant everyone is very helpful. They listen to every single problem of yours carefully and will ensure all required support and help is given. We came here after a lot of disappointments. But they ensure the treatment and all alternatives are given in the starting only. Thank you again for the support and understanding

The Makeup Diaries!!

After struggling for last 5 years, We have wonderfulexperience with the doctor & whole staff of INDIRAIVF NOIDA CENTRE , Doctor Mandavi ma'am is verygenerous & simple . All the staff are very easy going& supportive. I would like to mention the namespecially lovely Osheen ma'am, Shweta ma'am forguiding us in every situation. They are alwaysavailable on phone call for any guidance &emergencies. They treat like family not like Clint. Iwould like to thanks Prabhat ji karan ji & all otherstaff too for their wonderful support . We wish themall the success & best wishes from bottom of ourheart. Humble thanks!

PRIYA TIWARI

Thank you Dr Madhavi Madam and all the staff at Noida center. They have provided all possible solutions to become parenthood's and our dreams journey have been started just. All the best and Good luck from our side to start your journey soon. You can get an good and wonderful experience and support from them. Most important is that couples need to prepare mentally and physical too for this wonderful feelings. Just need to extend your support on financial part who need it most.

Mitul Makwana

My case was handed by Dr Mandavi Rai, she is very professional toward her work and All the staff members have been very helpful and friendly I believe it is one of the best gynecologist and ivf across Delhi NCR, if someone facing issue with infertility must visit indira ivf , sectors 18, Noida. Once again thank you so much Dr Mandavi rai and all the team members.

Surendra Pal

best staff every one is helping and kind Dr Mandavi mam is so careful and helping and amezing visit for good care

Geetika Agarwal

We started visting Indira IVF after a refreaal from Mumbai Indira IVF; Dr.Mandavi and Team are good and have taken good care of the baby during pregnancy; they advised right hospital for delivery and supported us; Thanks to Shevali and Oshi alog with Dr.Mandavi

Parkash Gurazada
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